PFLPhysiological Fitness Landscape

Clinical applications

From a list of results to a map with directions.

These are the uses the research is designed to make possible. None is in clinical use yet. Each depends on the validation described under Evidence.

A position report instead of a reference-range report

Every routine result placed on its hazard curve for the person's age and sex, with the combined picture across markers rather than a column of flags.

Prototype

Trajectory alerts

Flag people whose markers are moving toward a cliff, years before any value leaves its normal range.

Research

Choosing the intervention that moves someone furthest

Rank options by how far they are expected to lower this person's hazard, using catalogued effect sizes and the shape of the ground they stand on.

Research

Choosing the next test

Recommend the measurement that would most change the picture for this person, and skip the ones that would not.

Prototype

Trial design and enrichment

Enrol people on the steepest ground, where an effective intervention shows its effect soonest, and use landscape position as a shared outcome across trials.

Research

What a health system partnership looks like

Repeated routine labs on a defined population, analysed inside the partner's environment under its governance. Nothing identifiable leaves. The first output is a retrospective test: does landscape position and trajectory predict outcomes better than current risk scores?

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