Biomarkers · Aging & Senescence
Alpha-Klotho
Higher values carry lower risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio1.21top vs bottom quarter (95% CI 1.01–1.45) · NHANES 2007-2016, n=13,748 US adults aged 40-79, median follow-up 92 months, 1,569 deaths
Where people sit
Population percentiles (pg/mL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 488 | 682 | 860 | 1,085 | 1,517 | 13,751 | Yan S, Luo W, Lei L, Z… |
| All | 40-59 | 466 | 655 | 830 | 1,052 | 1,479 | 13,751 | Yan S, Luo W, Lei L, Z… |
| All | 60+ | 413 | 590 | 755 | 967 | 1,381 | 13,751 | Yan S, Luo W, Lei L, Z… |
| All | all | 430 | 630 | 800 | 990 | 1,400 | 13,751 | Yan S, Luo W, Lei L, Z… |
| Men | all | 439 | 643 | 816 | 1,010 | 1,428 | 13,751 | Yan S, Luo W, Lei L, Z… |
| Women | all | 421 | 617 | 784 | 970 | 1,372 | 13,751 | Yan S, Luo W, Lei L, Z… |
Sources
- Hazard curve: Synthesized from mortality_association (HR=1.21 quartile_extreme); per-SD log(HR)=0.149. Reported as quartile_extreme HR=1.21 for all-cause mortality. U-shaped association with inflection at log-klotho 6.917 pg/mL: both lowest quintile (HR
- Wei K, Zhang Q, Chen C, et al. Higher circulating alpha-klotho levels increase all-cause mortality through mediation effects of liver fibrosis: a second analysis of National Health and Nutrition Examination Survey. The Journals of Gerontology: Series A. 2025;80(7):glaf109.