Biomarkers · Liver & Nutritional
De Ritis Ratio (AST/ALT)
Lower values carry lower risk. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation is associated with a hazard ratio of 1.24. Reproduces in NHANES
NHANES, our fit with 95% CIPublished curve
Hazard ratios relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.
NHANES hazard per SD1.2495% CI 1.21–1.28 · 48,262 adults, 7,006 deaths
Published hazard ratio1.58top vs bottom quarter (95% CI 1.12–2.22) · NHANES, n=8068 (prevalence analysis) / n=8063 (mortality analysis), U.S. community-dwelling adults
Where people sit
Population percentiles (ratio) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 0.50 | 0.73 | 0.95 | 1.23 | 1.81 | 10,000 | Zhang H, Feng S. Assoc… |
| All | 40-59 | 0.57 | 0.81 | 1.03 | 1.32 | 1.87 | 10,000 | Zhang H, Feng S. Assoc… |
| All | 60+ | 0.65 | 0.90 | 1.12 | 1.41 | 1.95 | 10,000 | Zhang H, Feng S. Assoc… |
| All | all | 0.57 | 0.81 | 1.03 | 1.32 | 1.87 | 10,000 | Zhang H, Feng S. Assoc… |
| Men | all | 0.58 | 0.83 | 1.05 | 1.34 | 1.89 | 10,000 | Zhang H, Feng S. Assoc… |
| Women | all | 0.55 | 0.79 | 1.01 | 1.29 | 1.85 | 10,000 | Zhang H, Feng S. Assoc… |
Sources
- Hazard curve: Synthesized from mortality_association (HR=1.58 quartile_extreme); per-SD log(HR)=0.357. Reported as quartile_extreme HR=1.58 for all-cause mortality. Highest quartile (Q4) of De-Ritis ratio vs lowest quartile (Q1), fully adjusted model, p
- Zhang H, Feng S. Association of the De-Ritis (AST/ALT) ratio with coronary heart disease prevalence and all-cause mortality in U.S. adults: a national health and nutrition examination survey analysis. J Cardiothorac Surg. 2026;21:article.
- Empirical curve: our Cox model with age and sex, NHANES 1999–2018 with linked mortality to 2019.