Biomarkers · Aging & Senescence
DNA Methylation Age Acceleration (PhenoAge/GrimAge)
Lower values carry lower risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio1.22per SD (95% CI 1.08–1.25) · Meta-analysis of five prospective cohorts (Lothian Birth Cohorts 1921/1936, Framingham Heart Study offspring, Normative Aging Study, InCHIANTI), n>4000 older adults
Where people sit
Population percentiles (years) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
| All | 40-59 | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
| All | 60+ | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
| All | all | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
| Men | all | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
| Women | all | -9.87 | -4.04 | 0.00 | 4.04 | 9.87 | 9,926 | Levine ME, Lu AT, Quac… |
Sources
- Hazard curve: Synthesized from mortality_association (HR=1.2188335924130098 per_sd); per-SD log(HR)=0.198. Reported as per_unit HR=1.16 for all-cause mortality. HR per 5-year increment in Hannum-based DNA methylation age acceleration (Delta age), fully adju
- Marioni RE, Shah S, McRae AF, et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology. 2015;16(1):25.
Map DNA Methylation Age Acceleration (PhenoAge/GrimAge) against another biomarker.