Biomarkers · Hematology
Eosinophil Count
Higher values carry lower risk. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation is associated with a hazard ratio of 1.04. Opposite direction in NHANES
NHANES, our fit with 95% CIPublished curve
Hazard ratios relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.
NHANES hazard per SD1.0495% CI 1.02–1.06 · 48,954 adults, 7,151 deaths
Published hazard ratio2.20top vs bottom quarter (95% CI 1.84–2.62) · Clalit Health Services (Israel) nationwide cohort, 2000-2023; 3,822 individuals with severe eosinophilia (>5,000 cells/uL) matched 1:10 to subjects with normal eosinophil counts (~38,220 controls)
Where people sit
Population percentiles (10^3 cells/uL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 0.05 | 0.17 | 0.26 | 0.40 | 0.70 | 2,680 | 2017-2018 |
| All | 40-59 | 0.05 | 0.18 | 0.28 | 0.42 | 0.75 | 2,630 | 2017-2018 |
| All | 60+ | 0.06 | 0.19 | 0.30 | 0.44 | 0.80 | 2,790 | 2017-2018 |
| All | all | 0.05 | 0.18 | 0.28 | 0.42 | 0.75 | 8,100 | 2017-2018 |
| Men | all | 0.05 | 0.17 | 0.26 | 0.40 | 0.70 | 3,950 | 2017-2018 |
| Women | all | 0.05 | 0.19 | 0.30 | 0.44 | 0.80 | 4,150 | 2017-2018 |
Sources
- Hazard curve: Synthesized from mortality_association (HR=2.2 quartile_extreme); per-SD log(HR)=0.615. Reported as threshold HR=2.2 for all-cause mortality. Severe eosinophilia (>5,000 cells/uL) vs normal eosinophil count. Note: this is a threshold at a
- Clalit Health Services study group. Severe eosinophilia and risk of major disease and mortality: A nationwide cohort study of children and adults. PubMed. 2025.
- Empirical curve: our Cox model with age and sex, NHANES 1999–2018 with linked mortality to 2019.