Biomarkers · Vitamins & Endocrine
Insulin-like Growth Factor 1 (IGF-1)
U-shaped: both low and high values carry risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio1.33top vs bottom third (95% CI 1.14–1.57) · Meta-analysis of 19 prospective studies, n=30,876 participants (general population and mixed cohorts)
Where people sit
Population percentiles (ng/mL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 76.2 | 109 | 138 | 169 | 208 | 349 | MIDUS 3 Biomarker Proj… |
| All | 40-59 | 76.2 | 109 | 138 | 169 | 208 | 349 | MIDUS 3 Biomarker Proj… |
| All | 60+ | 64.7 | 99.0 | 127 | 152 | 209 | 360 | MIDUS 3 Biomarker Proj… |
| All | all | 67.0 | 104 | 132 | 162 | 208 | 737 | MIDUS 3 Biomarker Proj… |
| Men | all | 77.2 | 112 | 139 | 172 | 217 | 326 | MIDUS 3 Biomarker Proj… |
| Women | all | 61.5 | 99.0 | 125 | 155 | 196 | 411 | MIDUS 3 Biomarker Proj… |
Sources
- Hazard curve: Synthesized from mortality_association (HR=1.33 tertile_extreme); per-SD log(HR)=0.193. Reported as tertile_extreme HR=1.33 for all-cause mortality. Pooled HR for low vs middle IGF-1 category = 1.33 (1.14-1.57); high vs middle category HR
- Rahmani J, Montesanto A, Giovannucci E, et al. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Aging Cell. 2022;21(2):e13540.
Map Insulin-like Growth Factor 1 (IGF-1) against another biomarker.