Biomarkers · Hematology
Absolute Lymphocyte Count
U-shaped: both low and high values carry risk. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation is associated with a hazard ratio of 0.96. U-shaped: slope not comparable
NHANES, our fit with 95% CIPublished curve
Hazard ratios relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.
NHANES hazard per SD0.9695% CI 0.94–0.98 · 48,954 adults, 7,151 deaths
Published hazard ratio1.35top vs bottom third (95% CI 1.22–1.50) · NHANES 1999-2010 mortality linkage (CBC panel)
Where people sit
Population percentiles (10^3 cells/uL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 0.83 | 1.54 | 2.04 | 2.54 | 3.26 | 8,100 | Peto et al. 2017 (Mort… |
| All | 40-59 | 0.90 | 1.59 | 2.08 | 2.57 | 3.26 | 8,100 | Peto et al. 2017 (Mort… |
| All | 60+ | 1.02 | 1.68 | 2.14 | 2.59 | 3.25 | 8,100 | Peto et al. 2017 (Mort… |
| All | all | 0.92 | 1.61 | 2.10 | 2.59 | 3.28 | 8,100 | Peto et al. 2017 (Mort… |
| Men | all | 1.01 | 1.72 | 2.22 | 2.72 | 3.44 | 8,100 | Peto et al. 2017 (Mort… |
| Women | all | 0.83 | 1.51 | 1.98 | 2.45 | 3.13 | 8,100 | Peto et al. 2017 (Mort… |
Sources
- Hazard curve: Peto et al. 2017 (PMID 28858850) anchor; nhanes_cox_spline
- Peto MV, et al. MortalityPredictors.org: a manually-curated database of published results from longitudinal studies of mortality risk factors. Aging (Albany NY). 2017;9(9):1965-1983.
- Empirical curve: our Cox model with age and sex, NHANES 1999–2018 with linked mortality to 2019.