Mean Corpuscular Volume (MCV)

U-shaped: both low and high values carry risk. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation is associated with a hazard ratio of 1.06. U-shaped: slope not comparable

NHANES, our fit with 95% CIPublished curve

Hazard ratios relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.

NHANES hazard per SD1.0695% CI 1.03–1.08 · 49,105 adults, 7,188 deaths

Published hazard ratio1.29per SD (95% CI 1.04–1.06) · NHANES 1999-2008 with linked mortality follow-up, US general population adults, mean follow-up ~166 months

Value of the measurement+0.012gain in C within age bands; rank 30 of 56 · all tests

Where people sit

Population percentiles (fL) by sex and age band. Cycle or source as recorded in the catalogue.

Sex	Age	5th	25th	Median	75th	95th	n	Cycle / source
All	20-39	81.0	87.5	90.5	94.5	101	2,680	2017-2018
All	40-59	80.0	87.0	90.0	94.0	101	2,630	2017-2018
All	60+	79.5	86.8	89.8	93.8	101	2,790	2017-2018
All	all	80.0	87.0	90.0	94.0	101	8,100	2017-2018
Men	all	81.0	87.5	90.5	94.5	101	3,950	2017-2018
Women	all	79.0	86.5	89.5	93.5	100	4,150	2017-2018

Sources

Hazard curve: Synthesized from mortality_association (HR=1.2887965212762749 per_sd); per-SD log(HR)=0.254. Reported as per_unit HR=1.05 for all-cause mortality. U-shaped relationship with inflection point at MCV=88.6 fL. HR shown (1.05, 1.04-1.06) is the ad
Zhang J, et al. Nonlinear relationship of red blood cell indices (MCH, MCHC, and MCV) with all-cause and cardiovascular mortality: A cohort study in U.S. adults. PLOS ONE. 2024;19(8):e0307609.
Empirical curve: our Cox model with age and sex, NHANES 1999–2018 with linked mortality to 2019.

Map Mean Corpuscular Volume (MCV) against another biomarker.