Biomarkers · Neuro
Neurofilament Light Chain (NfL)
Lower values carry lower risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio1.88per SD (95% CI 1.60–2.20) · NHANES 2013-2014, n=2071 nationally representative US adults aged 20-85, followed up to 6 years (through 2019) via linked mortality file
Where people sit
Population percentiles (pg/mL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 2.85 | 4.20 | 5.50 | 7.20 | 10.6 | 1,724 | Simren J, Andreasson U… |
| All | 40-59 | 4.08 | 6.16 | 8.20 | 10.9 | 16.5 | 1,724 | Simren J, Andreasson U… |
| All | 60+ | 5.91 | 10.0 | 14.5 | 20.9 | 35.5 | 1,724 | Simren J, Andreasson U… |
| All | all | 3.13 | 5.65 | 8.50 | 12.8 | 23.0 | 1,724 | Simren J, Andreasson U… |
| Men | all | 3.25 | 5.80 | 8.67 | 13.0 | 23.1 | 1,724 | Simren J, Andreasson U… |
| Women | all | 3.02 | 5.50 | 8.33 | 12.6 | 23.0 | 1,724 | Simren J, Andreasson U… |
Sources
- Hazard curve: Synthesized from mortality_association (HR=1.88 per_sd); per-SD log(HR)=0.631. Reported as per_sd HR=1.88 for all-cause mortality. HR per 1-SD increase in log-transformed (Loge) serum NfL, adjusted model. A separate fully adjuste
- Beydoun MA, Noren Hooten N, Georgescu MF, Beydoun HA, Eid SM, Fanelli-Kuczmarski MT, Evans MK, Zonderman AB. Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults. European Journal of Epidemiology. 2024;39(8):887-900.
Map Neurofilament Light Chain (NfL) against another biomarker.