Biomarkers · Hematology
Serum Iron
U-shaped: both low and high values carry risk. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation is associated with a hazard ratio of 0.88. U-shaped: slope not comparable
NHANES, our fit with 95% CIPublished curve
Hazard ratios relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.
NHANES hazard per SD0.8895% CI 0.85–0.90 · 48,322 adults, 7,020 deaths
Published hazard ratio1.27top vs bottom third (95% CI 1.14–1.42) · NHANES III prospective mortality linkage (1988-2011)
Where people sit
Population percentiles (ug/dL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 27.5 | 64.8 | 90.7 | 117 | 154 | 7,700 | Peto et al. 2017 (Mort… |
| All | 40-59 | 40.7 | 78.2 | 104 | 130 | 168 | 7,700 | Peto et al. 2017 (Mort… |
| All | 60+ | 51.4 | 88.5 | 114 | 140 | 177 | 7,700 | Peto et al. 2017 (Mort… |
| All | all | 38.9 | 76.4 | 102 | 128 | 166 | 7,700 | Peto et al. 2017 (Mort… |
| Men | all | 55.4 | 92.6 | 119 | 144 | 182 | 7,700 | Peto et al. 2017 (Mort… |
| Women | all | 31.5 | 64.8 | 87.8 | 111 | 144 | 7,700 | Peto et al. 2017 (Mort… |
Sources
- Hazard curve: Peto et al. 2017 (PMID 28858850) anchor; nhanes_cox_spline
- Peto MV, et al. MortalityPredictors.org: a manually-curated database of published results from longitudinal studies of mortality risk factors. Aging (Albany NY). 2017;9(9):1965-1983.
- Empirical curve: our Cox model with age and sex, NHANES 1999–2018 with linked mortality to 2019.