Biomarkers · Urine Biomarkers
Urinary Creatinine Concentration
Higher values carry lower risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio0.78per SD (95% CI 0.68–0.89) · CRIC Study Prospective Cohort
Where people sit
Population percentiles (mg/dL) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 42.0 | 92.0 | 143 | 204 | 312 | 2,580 | 2017-2018 |
| All | 40-59 | 29.0 | 71.0 | 117 | 171 | 266 | 2,550 | 2017-2018 |
| All | 60+ | 22.0 | 54.0 | 89.0 | 133 | 208 | 2,670 | 2017-2018 |
| All | all | 28.0 | 69.0 | 116 | 173 | 272 | 7,800 | 2017-2018 |
| Men | all | 45.0 | 96.0 | 146 | 205 | 310 | 3,780 | 2017-2018 |
| Women | all | 21.0 | 55.0 | 91.0 | 136 | 218 | 4,020 | 2017-2018 |
What studies found when this marker was changed
Effects on the biomarker reported in the cited studies. They describe what happened in those populations, not a recommendation for anyone. See all catalogued interventions.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | Severe muscle wasting, advanced sarcopenia, and amputation | -40% to -70% low urinary creatinine (<600 mg/24hr) | prospective cohort | Baxmann AC, et al. Clin J Am Soc Nephrol. 2008;3:348-354. |
| diet | High-protein omnivorous dietary pattern | +10% to +25% increase | rct | Perrone RD, et al. Clin Chem. 1992;38:1933-1953. |
| exercise | Progressive resistance hypertrophy training increasing skeletal muscle mass | +15% to +30% increase in daily creatinine excretion | rct | Forbes GB, et al. Am J Clin Nutr. 1983;37:433-439. |
| lifestyle | Extensive overhydration / water intoxication (spot dilution <20 mg/dL) | -60% to -90% spot concentration dilution | mechanistic | Kesteloot H, et al. Lancet. 1996;347:489-493. |
| nutraceutical | Creatine monohydrate supplementation (5g/day) | +20% to +40% increase in total urinary creatinine excretion | rct | Persky AM, et al. J Clin Pharmacol. 2003;43:1025-1033. |