Biomarkers · Urine Biomarkers
Urinary Flow Rate
U-shaped: both low and high values carry risk. Not measured in our NHANES panel; the curve is synthesised from the published association.
Hazard ratio relative to the curve's reference value, as synthesised from the published association.
Published hazard ratio1.37top vs bottom quarter (95% CI 1.14–1.64) · Walkerton Health Study Cohort
Where people sit
Population percentiles (mL/min) by sex and age band. Cycle or source as recorded in the catalogue.
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | 20-39 | 0.30 | 0.66 | 1.10 | 1.82 | 3.85 | 2,480 | 2017-2018 |
| All | 40-59 | 0.28 | 0.62 | 1.03 | 1.70 | 3.60 | 2,460 | 2017-2018 |
| All | 60+ | 0.26 | 0.58 | 0.98 | 1.62 | 3.45 | 2,560 | 2017-2018 |
| All | all | 0.28 | 0.62 | 1.04 | 1.72 | 3.65 | 7,500 | 2017-2018 |
| Men | all | 0.29 | 0.64 | 1.06 | 1.75 | 3.75 | 3,650 | 2017-2018 |
| Women | all | 0.27 | 0.60 | 1.02 | 1.68 | 3.55 | 3,850 | 2017-2018 |
What studies found when this marker was changed
Effects on the biomarker reported in the cited studies. They describe what happened in those populations, not a recommendation for anyone. See all catalogued interventions.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | Adequate oral and intravenous volume resuscitation in shock | Restores urine flow > 0.5 mL/kg/hr, preventing acute kidney injury | rct | Rivers E, et al. N Engl J Med. 2001;345:1368-1377. |
| clinical | Acute tubular necrosis or complete urinary tract outflow obstruction | Oliguria (<0.3 mL/min) or absolute anuria (<50 mL/day) | clinical guideline | Bellomo R, et al. Crit Care. 2004;8:R204-R212. |
| clinical | Severe uncompensated hypovolemic or septic shock | -80% to -100% collapse in urine output | clinical guideline | Rhodes A, et al. Intensive Care Med. 2017;43:304-377. |
| diet | High water intake (>2.5 L/day) in recurrent nephrolithiasis | +50% to +100% flow increase, reducing kidney stone recurrence by 55% | rct | Borghi L, et al. J Urol. 1996;155:839-843. |
| pharmacologic | SGLT2 inhibitors inducing mild osmotic natriuresis | +300 to +500 mL/day increase in initial daily urine volume | rct | Heerspink HJ, et al. Circulation. 2016;134:752-772. |
Sources
- Hazard curve: Recalculated from mortality_association (HR=1.37 quartile_extreme); per-SD log(HR)=0.2456.
- Sontrop JM, et al. Association between volume of urine output and mortality in community-dwelling adults. Clin J Am Soc Nephrol. 2013;8(11):1948-1956.